Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors while in the central nervous process, conolidine modulates alternate molecular targets. A Science Developments research found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://andreie420bde1.theblogfairy.com/36772493/the-basic-principles-of-alternative-natural-pain-relief-to-replace-traditional-painkillers