There's a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent pain transmission and produce analgesia. For that reason, drugs like clonidine that concentrate on alpha-2 receptors can affect the transmission of suffering. Applies to clonidine: oral tablet, https://alcuinj495ryb7.evawiki.com/user